SidaGhanaV1, Main, Exploration, bibRecord, 000408

Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana

Identifieur interne : 000408 ( Main/Exploration ); précédent : 000407; suivant : 000409

Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana

Auteurs : Fred Stephen Sarfo [Ghana] ; Kirsten Alexandra Eberhardt [Allemagne] ; Albert Dompreh [Ghana] ; Edmund Osei Kuffour [Allemagne] ; Mareike Soltau [Allemagne] ; Marei Schachscheider [Allemagne] ; Jan Felix Drexler [Allemagne] ; Anna Maria Eis-Hübinger [Allemagne] ; Dieter H Ussinger [Allemagne] ; Emelia Efua Oteng-Seifah [Ghana] ; George Bedu-Addo [Ghana] ; Richard Odame Phillips [Ghana] ; Betty Norman [Ghana] ; Gerd Burchard [Allemagne] ; Torsten Feldt [Allemagne]

Source :

PLoS ONE [ 1932-6203 ] ; 2015.

RBID : PMC:4658036

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Charge virale, Co-infection, Facteurs de risque, Facteurs socioéconomiques, Femelle, Ghana (épidémiologie), Helicobacter pylori (immunologie), Humains, Infections à Helicobacter (immunologie), Infections à Helicobacter (épidémiologie), Infections à VIH (immunologie), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Infections à VIH (épidémiologie), Jeune adulte, Mâle, Numération des lymphocytes CD4, Prévalence, Rapport CD4-CD8, Thérapie antirétrovirale hautement active, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie).
MESH :
- immunologie : Helicobacter pylori, Infections à Helicobacter, Infections à VIH, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- traitement médicamenteux : Infections à VIH.
- virologie : Infections à VIH.
- épidémiologie : Ghana, Infections à Helicobacter, Infections à VIH.
- Adulte, Adulte d'âge moyen, Charge virale, Co-infection, Facteurs de risque, Facteurs socioéconomiques, Femelle, Humains, Jeune adulte, Mâle, Numération des lymphocytes CD4, Prévalence, Rapport CD4-CD8, Thérapie antirétrovirale hautement active.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-CD8 Ratio, Coinfection, Female, Ghana (epidemiology), HIV Infections (drug therapy), HIV Infections (epidemiology), HIV Infections (immunology), HIV Infections (virology), HIV-1 (immunology), Helicobacter Infections (epidemiology), Helicobacter Infections (immunology), Helicobacter pylori (immunology), Humans, Male, Middle Aged, Prevalence, Risk Factors, Socioeconomic Factors, Viral Load, Young Adult.
MESH :
- geographic , epidemiology : Ghana.
- drug therapy : HIV Infections.
- epidemiology : HIV Infections, Helicobacter Infections.
- immunology : HIV Infections, HIV-1, Helicobacter Infections, Helicobacter pylori.
- virology : HIV Infections.
- Adult, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, CD4-CD8 Ratio, Coinfection, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors, Socioeconomic Factors, Viral Load, Young Adult.

Abstract

Background

Worldwide, there is a high co-endemicity of HIV and H. pylori infection and there is growing evidence that H. pylori co-infection is associated with parameters of HIV disease progression. The objective of this study was to investigate the prevalence of H. pylori infection, and the association with clinical, immunological and virological parameters in a large cohort of HIV-infected individuals and uninfected controls in a West African country.

Methods

HIV-patients (n = 1,095) and HIV-negative individuals (n = 107) were recruited at a university hospital in Ghana. H. pylori status was determined using stool antigen testing. HIV-related, clinical and socio-demographic parameters were recorded and analyzed according to H. pylori status.

Results

The prevalence of H. pylori infection was significantly lower in HIV-positive compared to HIV-negative individuals (51.5 vs. 88%, p<0.0001). In HIV patients, H. pylori prevalence decreased in parallel with CD4+ T cell counts. In ART-naïve HIV-infected individuals, but not in those taking ART, H. pylori infection was associated with higher CD4 cell counts (312 vs. 189 cells/μL, p<0.0001) and lower HIV-1 viral loads (4.92 vs. 5.21 log10 copies/mL, p = 0.006). The findings could not be explained by socio-demographic confounders or reported use of antibiotics. Having no access to tap water and higher CD4+ T cell counts were identified as risk factors for H. pylori infection.

Conclusions

H. pylori prevalence was inversely correlated with the degree of immunosuppression. In ART-naïve individuals, H. pylori infection is associated with favorable immunological and virological parameters. The underlying mechanisms for this association are unclear and warrant investigation.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658036

DOI: 10.1371/journal.pone.0143388
PubMed: 26599971
PubMed Central: 4658036

Affiliations:

Le document en format XML

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 Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>Helicobacter pylori</italic>
 Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana</title>
<author><name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name>
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<author><name sortKey="Eberhardt, Kirsten Alexandra" sort="Eberhardt, Kirsten Alexandra" uniqKey="Eberhardt K" first="Kirsten Alexandra" last="Eberhardt">Kirsten Alexandra Eberhardt</name>
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</nlm:aff>
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<author><name sortKey="H Ussinger, Dieter" sort="H Ussinger, Dieter" uniqKey="H Ussinger D" first="Dieter" last="H Ussinger">Dieter H Ussinger</name>
<affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oteng Seifah, Emelia Efua" sort="Oteng Seifah, Emelia Efua" uniqKey="Oteng Seifah E" first="Emelia Efua" last="Oteng-Seifah">Emelia Efua Oteng-Seifah</name>
<affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Kumasi Centre for Collaborative Research, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Kumasi Centre for Collaborative Research, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Komfo Anokye Teaching Hospital, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Phillips, Richard Odame" sort="Phillips, Richard Odame" uniqKey="Phillips R" first="Richard Odame" last="Phillips">Richard Odame Phillips</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Komfo Anokye Teaching Hospital, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Kwame Nkrumah University of Science and Technology, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Kwame Nkrumah University of Science and Technology, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Komfo Anokye Teaching Hospital, Kumasi, Ghana</addr-line>
</nlm:aff>
<country xml:lang="fr">Ghana</country>
<wicri:regionArea>Komfo Anokye Teaching Hospital, Kumasi</wicri:regionArea>
<wicri:noRegion>Kumasi</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Burchard, Gerd" sort="Burchard, Gerd" uniqKey="Burchard G" first="Gerd" last="Burchard">Gerd Burchard</name>
<affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feldt, Torsten" sort="Feldt, Torsten" uniqKey="Feldt T" first="Torsten" last="Feldt">Torsten Feldt</name>
<affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Research Unit, Bernhard Nocht Institute for Tropical Medicine, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Düsseldorf</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Düsseldorf</region>
<settlement type="city">Düsseldorf</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Antiretroviral Therapy, Highly Active</term>
<term>CD4 Lymphocyte Count</term>
<term>CD4-CD8 Ratio</term>
<term>Coinfection</term>
<term>Female</term>
<term>Ghana (epidemiology)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (epidemiology)</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (virology)</term>
<term>HIV-1 (immunology)</term>
<term>Helicobacter Infections (epidemiology)</term>
<term>Helicobacter Infections (immunology)</term>
<term>Helicobacter pylori (immunology)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prevalence</term>
<term>Risk Factors</term>
<term>Socioeconomic Factors</term>
<term>Viral Load</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Charge virale</term>
<term>Co-infection</term>
<term>Facteurs de risque</term>
<term>Facteurs socioéconomiques</term>
<term>Femelle</term>
<term>Ghana (épidémiologie)</term>
<term>Helicobacter pylori (immunologie)</term>
<term>Humains</term>
<term>Infections à Helicobacter (immunologie)</term>
<term>Infections à Helicobacter (épidémiologie)</term>
<term>Infections à VIH (immunologie)</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Infections à VIH (virologie)</term>
<term>Infections à VIH (épidémiologie)</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Prévalence</term>
<term>Rapport CD4-CD8</term>
<term>Thérapie antirétrovirale hautement active</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ghana</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>HIV Infections</term>
<term>Helicobacter Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Helicobacter pylori</term>
<term>Infections à Helicobacter</term>
<term>Infections à VIH</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term>
<term>HIV-1</term>
<term>Helicobacter Infections</term>
<term>Helicobacter pylori</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ghana</term>
<term>Infections à Helicobacter</term>
<term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Antiretroviral Therapy, Highly Active</term>
<term>CD4 Lymphocyte Count</term>
<term>CD4-CD8 Ratio</term>
<term>Coinfection</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prevalence</term>
<term>Risk Factors</term>
<term>Socioeconomic Factors</term>
<term>Viral Load</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Charge virale</term>
<term>Co-infection</term>
<term>Facteurs de risque</term>
<term>Facteurs socioéconomiques</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Prévalence</term>
<term>Rapport CD4-CD8</term>
<term>Thérapie antirétrovirale hautement active</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title>
<p>Worldwide, there is a high co-endemicity of HIV and <italic>H</italic>
. <italic>pylori</italic>
 infection and there is growing evidence that <italic>H</italic>
. <italic>pylori</italic>
 co-infection is associated with parameters of HIV disease progression. The objective of this study was to investigate the prevalence of <italic>H</italic>
. <italic>pylori</italic>
 infection, and the association with clinical, immunological and virological parameters in a large cohort of HIV-infected individuals and uninfected controls in a West African country.</p>
</sec>
<sec id="sec002"><title>Methods</title>
<p>HIV-patients (n = 1,095) and HIV-negative individuals (n = 107) were recruited at a university hospital in Ghana. <italic>H</italic>
. <italic>pylori</italic>
 status was determined using stool antigen testing. HIV-related, clinical and socio-demographic parameters were recorded and analyzed according to <italic>H</italic>
. <italic>pylori</italic>
 status.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>The prevalence of <italic>H</italic>
. <italic>pylori</italic>
 infection was significantly lower in HIV-positive compared to HIV-negative individuals (51.5 vs. 88%, p<0.0001). In HIV patients, <italic>H</italic>
. <italic>pylori</italic>
 prevalence decreased in parallel with CD4+ T cell counts. In ART-naïve HIV-infected individuals, but not in those taking ART, <italic>H</italic>
. <italic>pylori</italic>
 infection was associated with higher CD4 cell counts (312 vs. 189 cells/μL, p<0.0001) and lower HIV-1 viral loads (4.92 vs. 5.21 log10 copies/mL, p = 0.006). The findings could not be explained by socio-demographic confounders or reported use of antibiotics. Having no access to tap water and higher CD4+ T cell counts were identified as risk factors for <italic>H</italic>
. <italic>pylori</italic>
 infection.</p>
</sec>
<sec id="sec004"><title>Conclusions</title>
<p><italic>H</italic>
. <italic>pylori</italic>
 prevalence was inversely correlated with the degree of immunosuppression. In ART-naïve individuals, <italic>H</italic>
. <italic>pylori</italic>
 infection is associated with favorable immunological and virological parameters. The underlying mechanisms for this association are unclear and warrant investigation.</p>
</sec>
</div>
</front>
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</author>
<author><name sortKey="Rao, Bv" uniqKey="Rao B">BV Rao</name>
</author>
<author><name sortKey="Rademaker, Jw" uniqKey="Rademaker J">JW Rademaker</name>
</author>
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</author>
</analytic>
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</author>
<author><name sortKey="Lucia, Lm" uniqKey="Lucia L">LM Lucia</name>
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<author><name sortKey="Acuff, Gr" uniqKey="Acuff G">GR Acuff</name>
</author>
</analytic>
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</author>
<author><name sortKey="Davidkov, L" uniqKey="Davidkov L">L Davidkov</name>
</author>
<author><name sortKey="Gergova, G" uniqKey="Gergova G">G Gergova</name>
</author>
<author><name sortKey="Kandilarov, N" uniqKey="Kandilarov N">N Kandilarov</name>
</author>
<author><name sortKey="Evstatiev, I" uniqKey="Evstatiev I">I Evstatiev</name>
</author>
<author><name sortKey="Panteleeva, E" uniqKey="Panteleeva E">E Panteleeva</name>
</author>
</analytic>
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<author><name sortKey="Carrick, J" uniqKey="Carrick J">J Carrick</name>
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<author><name sortKey="Turner, J" uniqKey="Turner J">J Turner</name>
</author>
<author><name sortKey="Lee, A" uniqKey="Lee A">A Lee</name>
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<author><name sortKey="Mitchell, H" uniqKey="Mitchell H">H Mitchell</name>
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<author><name sortKey="Cooper, Da" uniqKey="Cooper D">DA Cooper</name>
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<author><name sortKey="Tzias, V" uniqKey="Tzias V">V Tzias</name>
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<author><name sortKey="Charatsis, G" uniqKey="Charatsis G">G Charatsis</name>
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<author><name sortKey="Bliziotis, Ia" uniqKey="Bliziotis I">IA Bliziotis</name>
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<author><name sortKey="Doulgeroglou, V" uniqKey="Doulgeroglou V">V Doulgeroglou</name>
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<author><name sortKey="Arnold, I" uniqKey="Arnold I">I Arnold</name>
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<author><name sortKey="Rehrauer, H" uniqKey="Rehrauer H">H Rehrauer</name>
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<author><name sortKey="Weck, Mn" uniqKey="Weck M">MN Weck</name>
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<author><name sortKey="Nieters, A" uniqKey="Nieters A">A Nieters</name>
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<author><name sortKey="Andersen, Lp" uniqKey="Andersen L">LP Andersen</name>
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<author><name sortKey="Hartung, Ml" uniqKey="Hartung M">ML Hartung</name>
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<author><name sortKey="Muller, A" uniqKey="Muller A">A Muller</name>
</author>
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<author><name sortKey="King, M" uniqKey="King M">M King</name>
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<author><name sortKey="Murooka, Tt" uniqKey="Murooka T">TT Murooka</name>
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<author><name sortKey="Ghebremichael, M" uniqKey="Ghebremichael M">M Ghebremichael</name>
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</author>
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<author><name sortKey="Bunn, Je" uniqKey="Bunn J">JE Bunn</name>
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<author><name sortKey="Harding, M" uniqKey="Harding M">M Harding</name>
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<author><name sortKey="Sinha, A" uniqKey="Sinha A">A Sinha</name>
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</biblStruct>
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<author><name sortKey="Solnick, Jv" uniqKey="Solnick J">JV Solnick</name>
</author>
<author><name sortKey="De La Luz, Sanchez M" uniqKey="De La Luz S">Sanchez M de la Luz</name>
</author>
<author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name>
</author>
<author><name sortKey="Lin, Pl" uniqKey="Lin P">PL Lin</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Chang, Ah" uniqKey="Chang A">AH Chang</name>
</author>
<author><name sortKey="Sanchez, L" uniqKey="Sanchez L">L Sanchez</name>
</author>
<author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name>
</author>
<author><name sortKey="Haggerty, Td" uniqKey="Haggerty T">TD Haggerty</name>
</author>
<author><name sortKey="Parsonnet, J" uniqKey="Parsonnet J">J Parsonnet</name>
</author>
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</author>
<author><name sortKey="Sarfo, Fs" uniqKey="Sarfo F">FS Sarfo</name>
</author>
<author><name sortKey="Dompreh, A" uniqKey="Dompreh A">A Dompreh</name>
</author>
<author><name sortKey="Kuffour, Eo" uniqKey="Kuffour E">EO Kuffour</name>
</author>
<author><name sortKey="Geldmacher, C" uniqKey="Geldmacher C">C Geldmacher</name>
</author>
<author><name sortKey="Soltau, M" uniqKey="Soltau M">M Soltau</name>
</author>
</analytic>
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</TEI>
<affiliations><list><country><li>Allemagne</li>
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</country>
<region><li>District de Cologne</li>
<li>District de Düsseldorf</li>
<li>Hambourg</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Bonn</li>
<li>Düsseldorf</li>
<li>Hambourg</li>
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<name sortKey="Bedu Addo, George" sort="Bedu Addo, George" uniqKey="Bedu Addo G" first="George" last="Bedu-Addo">George Bedu-Addo</name>
<name sortKey="Dompreh, Albert" sort="Dompreh, Albert" uniqKey="Dompreh A" first="Albert" last="Dompreh">Albert Dompreh</name>
<name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name>
<name sortKey="Norman, Betty" sort="Norman, Betty" uniqKey="Norman B" first="Betty" last="Norman">Betty Norman</name>
<name sortKey="Oteng Seifah, Emelia Efua" sort="Oteng Seifah, Emelia Efua" uniqKey="Oteng Seifah E" first="Emelia Efua" last="Oteng-Seifah">Emelia Efua Oteng-Seifah</name>
<name sortKey="Phillips, Richard Odame" sort="Phillips, Richard Odame" uniqKey="Phillips R" first="Richard Odame" last="Phillips">Richard Odame Phillips</name>
<name sortKey="Phillips, Richard Odame" sort="Phillips, Richard Odame" uniqKey="Phillips R" first="Richard Odame" last="Phillips">Richard Odame Phillips</name>
<name sortKey="Sarfo, Fred Stephen" sort="Sarfo, Fred Stephen" uniqKey="Sarfo F" first="Fred Stephen" last="Sarfo">Fred Stephen Sarfo</name>
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<name sortKey="Burchard, Gerd" sort="Burchard, Gerd" uniqKey="Burchard G" first="Gerd" last="Burchard">Gerd Burchard</name>
<name sortKey="Drexler, Jan Felix" sort="Drexler, Jan Felix" uniqKey="Drexler J" first="Jan Felix" last="Drexler">Jan Felix Drexler</name>
<name sortKey="Eis Hubinger, Anna Maria" sort="Eis Hubinger, Anna Maria" uniqKey="Eis Hubinger A" first="Anna Maria" last="Eis-Hübinger">Anna Maria Eis-Hübinger</name>
<name sortKey="Feldt, Torsten" sort="Feldt, Torsten" uniqKey="Feldt T" first="Torsten" last="Feldt">Torsten Feldt</name>
<name sortKey="Feldt, Torsten" sort="Feldt, Torsten" uniqKey="Feldt T" first="Torsten" last="Feldt">Torsten Feldt</name>
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</record>

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Le SIDA au Ghana (serveur d'exploration)

Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana

Helicobacter pylori Infection Is Associated with Higher CD4 T Cell Counts and Lower HIV-1 Viral Loads in ART-Naïve HIV-Positive Patients in Ghana

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	Le SIDA au Ghana (serveur d'exploration)
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